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Top of pageIL 12, IL 23, AND IL 17Mtb is a potent inducer of the interleukin (IL) 12p40 subunit cytokine, and deficiency in this cytokine leads to susceptibility to mycobacterial disease in humans.7 This cytokine can be expressed as a homodimer or as a heterodimer with either the IL 12p35 or the IL 23p19 subunits, which signal through the IL 12 receptor chain (IL 12R in conjunction with the IL 12R or the IL 23R, respectively.8 IL 12p40 is induced and rapidly expressed in response to Mtb by ligation of Toll like receptor (TLR)9 in vivo or TLR2 and TLR9 in vitro.9 In the mouse model, early production of IL 12p40 is not accompanied by substantial IL 23p19 or IL 12p35, but the homodimer of IL 12p40 nike roshe run all black (IL 12p80 hereafter) can drive immature dendritic cells to develop a migratory phenotype and to activate naive T cells in the draining nike air max 90 ultra br - black dark grey white lymph node10 (Figure 1). There is also an alternative splice variant of the IL 12R which is induced in dendritic cells by mycobacteria and which augments the ability of IL 12p80 to drive dendritic cell migration and T cell activation.11 IL 12p80 has also been shown to restore the lost delayed hypersensitivity response in IL 12p35 mice.12 Although the ability of IL 12p80 to affect cell migration and delayed type hypersensitivity cannot be assessed directly in the human lungs, the alternative splice variant is induced in human peripheral blood cells by mycobacteria11 and IL 12p80 has also been identified in bronchoalveolar lavage of patients with asthma,13 suggesting that this cytokine could have a role in the initiation of cellular events in the human lung exposed to tuberculosis (TB). The exposure of lung phagocytes to invading Mtb results in binding of the bacteria and bacterial products to specific receptors, which then induce innate cytokine production by the infected cell.

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