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Statistical methodsAssociations between the expression levels of biomarkers and the IC50 values were analysed using Spearman's correlation, and differences in the IC50 values between subgroups compared using the Mann U test. All statistical tests were two sided. The threshold for upregulation was set to log (ratio) with a P value and downregulation was defined as log (ratio) 0.13 with a P value The P values were determined according to the Agilent error model when the feature extracted data were imported into Resolver.

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